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How long will it take for Prozac to work? Sleep, energy, or appetite may show some improvement within the first 1-2 weeks. Improvement in these physical symptoms can be an important early signal that the medication is working. Depressed mood and lack of interest in activities may need up to 6-8 weeks to fully improve.
Does sertraline make you sleepy? Sertraline may affect your sleep You can feel drowsy in the first few days of taking sertraline. If it makes you feel drowsy, try taking it just before you go to bed. You could also, strangely, have difficulty getting to sleep (insomnia), and disturbing dreams or nightmares.
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