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How effective is PEP at 72 hours? PEP must be started within 72 hours (3 days) after a possible exposure to HIV. PEP is effective in preventing HIV infection when it's taken correctly, but it's not 100% effective.
Is PrEP effective after 4 days? Daily Truvada (tenofovir/emtricitabine) as pre-exposure prophylaxis (PrEP) against HIV takes five to seven days to reach top estimated effectiveness among men who have sex with men (MSM), HIVandHepatitis.com reports. High levels of protection are maintained for perhaps a week after the last dose.
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