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How long does it take for cisplatin to work? You have chemotherapy as a course of several sessions (or cycles) of treatment over a few months. Each cycle of cisplatin usually takes 21 days (three weeks). Is cisplatin a strong chemo drug? Platinum-based chemotherapy drugs are among the most powerful and widely used against cancer. However, they have toxic side effects, and tumors can become resistant to them. Cisplatin, the most common platinum chemotherapy drug, was first approved in the US in 1978.
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