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How do you give mesna with cyclophosphamide? A similar regimen may be used for high-dose cyclophosphamide therapy. Administer a mesna IV bolus at a dose of 10% (w/w) of the ifosfamide dosage 15 minutes before beginning the continuous IV infusion, then follow with a continuous IV infusion of mesna at a dose of 100% (w/w) of the ifosfamide dosage. 7gtk70ik
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