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What is hydroxyurea toxicity? Hydroxyurea is an extremely toxic drug with a low therapeutic index. Since hydroxyurea inhibits DNA synthesis, it can result in significant toxicity, including myelosuppression. Furthermore, inhibition of DNA synthesis without affecting RNA synthesis may result in red blood cells becoming megaloblastic.
What happens when you take pills on an empty stomach? Some medicines need to be taken "before food" or "on an empty stomach ". This is because food and some drinks can affect the way these medicines work. For example, taking some medicines at the same time as eating may prevent your stomach and intestines absorbing the medicine, making it less effective.
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